N+1 AdaptX
MPF Systems
N+1 asked a simple question when designing this system, what is more efficient and cost affective for a business, having to go to 3 or 4 different vendors to purchase a specific asset for just one unit operation in your workflow, or buying one asset that can deliver all of these unit operations in a single package with additional forward thinking features? We believe the business benefits are obvious and are thus excited to introduce the N+1 AdaptX line of filtration systems.
AdaptX MPF (Multi Purpose Filtration) Systems can be used with your choice of hollow fiber or flat sheet filters and are available in benchtop, pilot, and full production scale systems. AdaptX systems come out of the box capable of 6 unique unit operational configurations.
Asymmetric Dialysis
Co / Counter Current Flow Perfusion
Traditional Ultrafiltration / Diafiltration
Single Pass Tangential Flow Filtration
Viral Filtration with Inline Gold Particle Testing
Microfiltration
Inside of its space conscious footprint AdaptX filtration systems are fully redundant with each identical side capable of separate operations in series or in parallel. This allows AdaptX to either handle double the filtration surface area or be used in series to achieve higher process concentrations or to be run semi continuously with process streams from one half of the system feeding the subsequent downstream operation on the other side of the system.
Did we mention that AdaptX systems are also out of the box inline dilution capable to cut down the floorspace needed for your diafiltration buffer?
AdaptX benchtop and cGMP suite systems are powered by a customers choice of CFR 21 Part 11 compliant automation packages including N+1 Liminal, Siemens, Rockwell, or DeltaV options as well as customizable mixing point outlet(s).
With all of its functionality the N+1 Engineering Team looks forward to how your organization uses its AdaptX MPF System to unlock a cheaper, more robust manufacturing process.
Sincerely,
Your N+1 Engineering Team
AdapatX MFP
A modular, multi unit operation, filtration system built to provide forward thinking flexibility and multi purpose functionality for your pharmaceutical workflow
System Features:
Benchtop (1/8” - 3/8”) or cGMP Suite Models (1/8”-1”)
Minimum Two Flow Kit Scales Per System Size
Flow Kit Range: 1/8” - 1” I.D. Tubing
Levitronix Pumps, Equilibar Control Valves, Levitronix Flow Meters Standard
Customer Preferred Automation (N+1 Liminal, Siemens, Rockwell, DeltaV)
NEMA 4x (CE Rating Optional)
Inline Dilution Capable
Fully Redundant Half Systems (Standard)
Hollow Fiber and Flat Plate Filter Compatible
High Pressure or Low Pressure Configurations
Modular Single Use Manifolds Drive Multi Unit Op Functionality Economically:
Capability at your finger tips when you need it.
Unlike other suppliers, AdaptX incorporates a modular single use design that allows your operations to control which functionality is utilized when for a given unit operation.
With AdaptX your operations team does not need to worry about installation of bulky single use flow kits in your clean room that are easily damaged. AdaptX modular single use manifolds are designed to be intuitive, easily installed, light weight, and easy to package and ship, resulting in less errors, less damage, and an overall cleaner user setup and breakdown experience.
This also allows the end user to keep their unit operational costs as optimized as possible by only consuming the optimized configuration that they need for unit operation execution.
The modular approach also allows the AdaptX skid the open architecture engineering to accommodate any filter, hollow fiber or flat sheet and be designed to fully maximize your processes filter utilization strategy whether single or multi use.
Unlocking Next Generational Functionality & Robustness with AdaptX MPF Systems:
AdaptX Filtration Systems where designed to not just simply the user installation experience but to allow your organization to unlock next generational manufacturing efficiencies out of the box by simply connecting together the AdaptX modular manifolds.
Let’s start with the most simple efficiency. Two unit operations on a single skid operating in series. On an AdaptX system this is possible. As an example: setup one half of your AdaptX system to perform Viral Filtration, setup the other side to run Single Pass Tangential Flow Filtration or Recirculated Ultrafiltration and Diafiltration and instantly your operations team gains the benefit of a single platform running a semi continuous manufacturing process within your downstream suite at an exponentially reduced floorspace footprint.
Need to perform a concentration that would normally require two UF/DF steps in series? Great! the AdaptX can run one UF/DF filter on one half the system and have it flow continuously or through a break tank into the second UF/DF process on the other half of the skid.
Want to try and achieve the benefits of Asymmetric Dialysis in lowing the total necessary diafiltration buffer volumes of your process and running a traditional UF/DF as a now single pass operation? Excellent! Use AdaptX’s out of the box Asymmetric Dialysis Automation with your choice of single use filter and our modular single use manifolds and gain those benefits.
Trying to optimize your perfusion process within the lab? Try AdaptX Co-flow Perfusion, Counter Current Flow, or a combination of both techniques using the systems multiple perfusion configurations on the AdaptX Benchtop Scale System and know that your perfect process is then easily scaled to the AdaptX Pilot and Full Scale Systems.
Have you always wanted to inline dilute your filtration buffer onto your single use system to gain floor print savings for your process and make it easier for operators to move your needed volumes of filtration buffer around your facility? Excellent idea, just use AdaptX pumps and its out of the box inline dilution automation with your filtration operation of choice to help facilitate your goal. And better yet characterize that exact process optimization on the benchtop system before bringing it into your full scale GMP environment easily across a linearly scalable platform.
With its commitment to open architecture and adaptable functionality we look forward to seeing how you use your AdaptX filtration system.
System Specifications
Product Scale
Benchtop
Flow Sensor Range
1/8” - 0-1 L/min 1/4” - 0-4 L/min
Flow Sensor Accuracy
1.5%
Pressure Sensor Range
UV Sensor Wavelength Range
UV Sensor Measurement Range
UV Sensor Accuracy
Pilot Scale
0-60 psig
Pressure Sensor Accuracy
+/- 0.5% FS
Compatible Single Use Sizes
Pump Configurations
Pump Range
0 - 7000 RPM
200 - 2400 nm
0-3 AU
1% 0-2 AU 2% 2-3 AU
Full Scale
3/8” - 0-20 L/min 1/2” - 0-50 L/min
3/4” - 0-80 L/min 1” 0 -160 L/min
1%
1/8” I.D 1/4” I.D.
1%
0-60 psig
0-60 psig
+/- 0.5% FS
3/8” I.D 1/2” I.D.
Low Pressure High Pressure
+/- 0.5% FS
3/4” I.D 1” I.D.
Low Pressure High Pressure
Low Pressure High Pressure
0 -7000 RPM
0 -7000 RPM
200 - 2400 nm
200 - 2400 nm
0-3 AU
0-3 AU
1% 0-2 AU 2% 2-3 AU
1% 0-2 AU 2% 2-3 AU