Improving Your LNP Process Efficiency and Quality With the N+1 LNP System Featuring the Benefits of Using Levitronix Pumps for Fluid Delivery

Built to Improve Your LNP Process Efficiency and Quality:

N+1 Systems are designed to not just deliver exceptional value but are designed for improving process quality and efficiency through our selection and patented configurations of superior components. This is why N+1 has focused its Liquid Nano Particle (LNP) platform around Levitronix for our open architecture skidded system for the Lipid Encapsulation Step for biopharmaceutical drug formulation and delivery.

Independent Third Party Testing conducted at bioX and summarized in the report LNP Manufacturing Small Scale T-Mix Pump Comparison replicating an established LNP encapsulation process provides data that strongly supports our chosen single use technology design standard. When comparing, in triplicate, an analogous flow kit configuration to the N+1 LNP System, process performance showed a statistically significant advantage to running a process using the Levitronix PuraLev-i30SU over alternatives of  Quattroflow, and MasterFlex.

The Levitronix PuraLev-i30SU process demonstrated superior process performance characteristics in Particle Size, Polydispersity Index (PDI), Encapsulation Efficiency, and Zeta Potential (Z-Average) under the following encapsulation process parameters:

Particle Size Target: 80 nm

Polydispersity Index (PDI): <0.20

Encapsulation Efficiency: >90%

Zeta Potential (Z-Average): -30 to -10 mV

Comparison of Levitronix to Quattroflow and Masterflex pump driven systems.

But what about microfluidics?

N+1’s independent fluid testing on our LNP Skidded System demonstrates that our Levitronix driven skidded system can accommodate the pressure drops associated with microfluidic applications. We are happy to work with our customers to help them integrate their microfluidic elements of preference into our flow kits to further optimize their encapsulation processes or meet final customer specifications.

This is more evidence as to the strength of our strategy, when designing your LNP process or just trying to drive more efficiency out of your current manufacturing process the choice is simple. Achieve higher efficiency in Particle Size Control, PDI, Encapsulation Efficiency, and Zeta Potential using the LNP System with Levitronix from N+1.

N+1: Designed for the Process by Process Engineers

To learn more and contact our team visit: n1processengineeringsolutions.com

Appendix: Independent Lab Tested LNP Process Conditions and Study Results

Study Results: